Showing posts with label diseases. Show all posts
Showing posts with label diseases. Show all posts

Tuesday, February 4, 2020

What makes the 2019 Novel Coronavirus so deadly?

What makes the 2019 Novel Coronavirus so deadly? | Healthbiztips
What makes the 2019 Novel Coronavirus so deadly? | Healthbiztips


Why the 2019 Novel Coronavirus is deadly? | Healthbiztips


@healthbiztips by Arlene Gentallan

First emerged in the city of Wuhan in China, this new strain of coronavirus, called the 2019 novel coronavirus, has been declared by the World Health Organization as a global health emergency. Infecting thousands and claiming hundreds in it's wake, this ailment significantly heightened the public's fear, but what makes it so notorious and lethal?

Although signs and symptoms of the 2019 novel coronavirus may appear atypical with manifestations of fever, cough, and breathing difficulty, reported deaths are primarily brought by the development of pneumonia and respiratory distress.

One source of concern among healthy individuals that are afflicted with this illness is the developement of cytokine storm in which the body's immune's system goes out of control resulting to damage in vital organs such as in the lungs and kidneys which can ultimately lead to the demise of the infected person. The problem with cytokine storm is that the more robust the immune system of the individual, the more damage it does to the body as it goes haywire causing fluid build-up and unnecessary inflammation. Note however, that cytokine storm is not the hallmark of the 2019 novel coronavirus as it can also occur as a result of some other forms of infectious diseases.

What is more, this disease is especially fatal to the vulnerable part of the population such as those afflicted with cancer, are immunocompromised, at the extremes of age (young and old) since their weak immune system is unable to fight off an infection.

Although much is said about the potential danger of the 2019 novel corona virus, it is worth mentioning that the death rate of 2019-nCoV (2019 novel corona virus) is very low at just 2% which means that only 2 people out of 100 infected died. In comparison to ebola with a mortality rate of more than 50%, 2019 nCoV isn't as deadly.

Considering that this is a newly discovered disease, there is no vaccine nor medicine that has yet been made to treat it. Treatment is primarily supportive which includes hydration and assisted ventilation.

Adding insult to the injury, the outbreak in Wuhan China shows the world that a citywide infestation is possible, yet most of the nations, especially the developing ones, may not have enough resources to isolate and manage it.

Another source of alarm is that those afflicted with this brand-new disease are believed to be able to transmit it even before they show visible symptoms. Incubation period of this disease can be as short as 2 days or as long as 14 days at which time a person may be unknowingly spreading the infection.

This novel virus is a part of a larger family of coronavirus whose various strains are  identified as the causative agent of common cold, SARS, and MERS.


Friday, November 9, 2018

What? Kill Cancer with Measles Virus?

Breakthrough: Measles virus hold potential for cancer treatment.

Have you read the news? Measles Virus Kills Cancer

What? Kill Cancer with Measles Virus?
What? Kill Cancer with Measles Virus?

@healthbiztips by Arlene Gentallan

Cancer is hard to battle. In search for better ways to kill this deadly disease, let's talk about viruses, particularly measles.

A normal person will definitely dread the idea of contracting measles, but recent breakthrough reveals it can offer an effective way to fight cancer.

This may sound horrifying, but the potential of using virus for cancer treatment became evident when tumor growth progression deteriorated among some cancer patients who contracted viral illness.

One success story of using measles virus against cancer is the case of Stacy Erholtz who had a remission of multiple myeloma after she received a single dose containing massive amounts of attenuated measles virus courtesy of Mayo Clinic. Do note that the measles virus she received were laboratory engineered to be weaker.


How do measles virus kill cancer?

Attenuated measles virus' success against cancer cells lies in their preference for CD46 which is abundant in tumor cells.


Why choose Measles virus?

Among other virus, measles virus was selected for cancer treatment because it's strain is less volatile, which means it is less likely to create new strain.

You'll get a better picture of how stable measles virus is when you compare it to influenza virus. Influenza virus easily develops new strain so we are unable to gain a foolproof immunity against it, which is the reason people get their flue shot every single year.

It is crucial that the strain of virus used for cancer treatment do not cause a widespread infection. The risk of measles outbreak is lessened by the fact that a huge portion of the population is immune against this disease owing to successful vaccination. In addition, a person can develop a lifelong immunity after naturally acquiring this disease.

This oncolytic virus sounds promising but it's still at clinical trial.